Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
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Most Useful Reviews
9
Skin improvement
50 people found this helpful
I bought this based on feedback and have no regrets. After a few days, I noticed an improvement in my skin and mobility. My legs no longer hurt as they used to; it’s remarkable!
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9
Joint health enhancement
16 people found this helpful
Gialuroka is a must-have for everyone! Hyaluronic acid, found in connective tissues, is essential for moisture retention, aiding not just the skin but also joints and bones. As we age, our bodies produce less hyaluronic acid, resulting in issues like bone pain. This supplement helps maintain joint health and is beneficial for proactive prevention.
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9
Prevents joint issues
14 people found this helpful
This hyaluronic acid is exceptional! It’s crucial for maintaining the body’s water balance and preventing problems associated with bone pain. From aiding skin moisture to protecting joints and cartilage, it helps retain youthful vitality. A deficiency can lead to joint issues and increased friction—this supplement is vital for those experiencing bone pain.
Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
User Reviews
USERS' SCORE
Good
Based on 33 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
Skin improvement
50 people found this helpful
I bought this based on feedback and have no regrets. After a few days, I noticed an improvement in my skin and mobility. My legs no longer hurt as they used to; it’s remarkable!
Read More
9
Joint health enhancement
16 people found this helpful
Gialuroka is a must-have for everyone! Hyaluronic acid, found in connective tissues, is essential for moisture retention, aiding not just the skin but also joints and bones. As we age, our bodies produce less hyaluronic acid, resulting in issues like bone pain. This supplement helps maintain joint health and is beneficial for proactive prevention.
Read More
9
Prevents joint issues
14 people found this helpful
This hyaluronic acid is exceptional! It’s crucial for maintaining the body’s water balance and preventing problems associated with bone pain. From aiding skin moisture to protecting joints and cartilage, it helps retain youthful vitality. A deficiency can lead to joint issues and increased friction—this supplement is vital for those experiencing bone pain.
Read More
9
Effective price value
7 people found this helpful
I have an arthritic big toe and had previously relied on lidocaine injections for relief. Introduced to hyaluronic acid by a nutritionist, I saw significant improvement after three weeks of using the liquid form. I discovered this product, which offers a better price per mg, and after two months, my pain has diminished completely. I'm absolutely thrilled with the relief it has provided.
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9
Back pain eased
4 people found this helpful
My husband has severe back pain from carrying heavy loads. After starting a course of hyaluronic acid with chondroitin, he noticed a significant reduction in his back pain, enabling him to move more comfortably.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Hyaluronic acid is a naturally occurring substance in the body, particularly abundant in connective tissues, skin, and eyes. It plays a crucial role in retaining moisture, making it vital for maintaining healthy skin hydration and elasticity. As a humectant, hyaluronic acid can hold up to 1,000 times its weight in water, which is why it's a favored ingredient in many skincare products. When applied topically, it helps to draw moisture into the skin, leaving it plump and well-hydrated.
In addition to its hydrating properties, hyaluronic acid has gained popularity for its potential anti-aging benefits. It helps to diminish the appearance of fine lines and wrinkles by creating a smoother skin texture. Many experts recommend incorporating hyaluronic acid into your skincare routine, particularly if you have dry or dehydrated skin, as it can complement other treatments and products effectively. Overall, hyaluronic acid is an essential component for those seeking to enhance their skin’s moisture levels and achieve a youthful glow.
Based on user reviews, the time it takes to see results from hyaluronic acid supplements can vary significantly among individuals. Some users report noticing improvements in a matter of days; for instance, one user mentioned a remarkable reduction in pain and increased mobility just a few days after starting the supplement Read Review. Alternatively, other users observed benefits after several weeks or up to three months of consistent use. For example, a user indicated that after two weeks, there was a noticeable reduction in knee swelling and pain Read Review.
Most users agree that consistent use is key to experiencing the full benefits of the supplement. One reviewer emphasized that her mother's pain decreased significantly, although she noted that taking the supplement regularly was important for maintaining its effects Read Review. Overall, while some may experience benefits quickly, a period of several weeks to a few months seems typical for many users to feel the full impact of these supplements on bone pain.
This supplement, polynucleotide sodium, shows potential in alleviating bone pain specifically related to knee osteoarthritis, based on a pilot study comparing it to hyaluronic acid. In this study, patients who received polynucleotide sodium injections demonstrated a significant reduction in weight-bearing pain after six weeks, suggesting that it may be more effective than traditional treatments for knee pain [1]. Despite this promising result, it's important to note that the study was limited in scope and did not show notable differences in other measures of pain or quality of life between the groups.
While the findings indicate that polynucleotide sodium can offer relief for weight-bearing pain in the knees, further research with larger sample sizes is necessary to fully support its use as a treatment for bone pain in broader contexts. As of now, if you're considering this supplement for bone pain relief, it might be worth discussing with your healthcare provider, especially given the preliminary nature of the results.
Many users have reported substantial improvements in their symptoms after taking hyaluronic acid supplements, particularly in relation to joint pain and mobility. For instance, one user noted a significant reduction in back pain that allowed for more comfortable movement shortly after beginning treatment with a combination of hyaluronic acid and chondroitin Read Review. Another reviewer mentioned that after a month of use, the knee pain that disrupted their mother's sleep has notably disappeared, highlighting the supplement's effectiveness in enhancing joint comfort Read Review.
Additionally, individuals have described rapid assessment of relief; for example, one user experienced a decrease in arm pain within only a week of starting the regimen Read Review. This trend of users reporting enhanced mobility and reduced pain suggests that while individual outcomes can vary, many find remarkable improvements in symptoms associated with joint discomfort after consistent use of hyaluronic acid supplements. Overall, anecdotal evidence points towards a beneficial impact on joint health, which seems particularly advantageous for users with a history of pain or stiffness.
Users have reported finding significant benefit in combining hyaluronic acid with other supplements like chondroitin and collagen for managing bone pain and joint health. Many reviews highlight the synergetic effects of these combinations, with one user noting a substantial reduction in their husband’s severe back pain when using hyaluronic acid alongside chondroitin Read Review. Another user shared that incorporating vitamin C into her mother’s regimen with hyaluronic acid led to a complete disappearance of nighttime knee pain Read Review.
Additionally, users have echoed that this combination offers a broader spectrum of benefits, improving mobility and easing discomfort more effectively than standalone use. For instance, one reviewer commented on the impressive results experienced after taking a product that included both hyaluronic acid and collagen; they observed reduced pain and stiffness in their joints, which greatly enhanced their flexibility Read Review. As such, many users expressed a preference for products that combine these ingredients for enhanced relief from bone pain.
Based on user reviews, it appears that there isn't a one-size-fits-all approach to the dosage of Hyaluronic Acid for treating bone pain. Many users reported noticeable improvements in their conditions after consistently using the supplement, although individual experiences varied. For example, one reviewer noted that their mother's joint pain significantly diminished with consistent use, while another user mentioned taking two capsules daily, which effectively reduced the swelling and pain associated with their Osgood-Schlatter disease Read ReviewRead Review.
Further insights reveal that supplements containing Hyaluronic Acid might work best when combined with other supportive nutrients like chondroitin and collagen. Reviewers indicated that consistency in taking the supplement was crucial for optimal results, suggesting that a regular regimen should be maintained to experience its full benefits. The general consensus emphasizes that while individual responses can vary greatly, maintaining a regular intake seems to lead to significant improvements in joint comfort and mobility Read ReviewRead Review.
9
Skin improvement
50 people found this helpful
I bought this based on feedback and have no regrets. After a few days, I noticed an improvement in my skin and mobility. My legs no longer hurt as they used to; it’s remarkable!
7.5
Decreased bone pain
1 people found this helpful
I have Osgood-Schlatter disease. After two weeks of taking this, the aching pain has diminished. The swelling in my knee has also reduced, and my cartilage seems to be recovering. I take two capsules a day and will be ordering more. Thank you!
8
Lessened bone pain
1 people found this helpful
I bought this for my mother, who struggles with joint problems and arthrosis. Her pains have greatly diminished. However, it's important to take it consistently; even with irregular intake, the effect is apparent! I recommend it.
9
Back pain eased
4 people found this helpful
My husband has severe back pain from carrying heavy loads. After starting a course of hyaluronic acid with chondroitin, he noticed a significant reduction in his back pain, enabling him to move more comfortably.
9
Knee pain relief
1 people found this helpful
My mother struggled with knee pain. After taking this remedy along with vitamin C for a month, the pain that used to disturb her at night has disappeared, and her joints are no longer "crunching." We've ordered two more jars for continued use.
7.5
Joint pain reduction
2 people found this helpful
Working! She was initially sceptical, but within a week, her joint pain decreased, and the swelling subsided. There's a noticeable improvement in the skin. I plan to continue for three months.
9
Noticeably improved condition
1 people found this helpful
Super effect! I have been using BioCell Collagen Hyaluronic Acid and Chondroitin Sulfate for a few weeks with noticeable results. This isn't my first time using this brand; I'm always satisfied with the efficiency. The combination helped reduce pain and stiffness in my joints, enhancing my flexibility and mobility. I'm astonished by how quickly I felt an improvement and highly recommend it for anyone facing joint problems.
7.5
Improved joint condition
8 people found this helpful
Hyaluronic acid in vegetarian capsules is wonderful for preserving beauty and youth! It plays a critical role in cartilage elasticity and joint lubrication. Research shows it aids in healing and reducing inflammatory responses, significantly reducing bone pain, particularly in conjunction with chondroitin and collagen.
8
Polynucleotide sodium reduces knee pain
Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
References
Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. 10.3390/jcm10051138